Holby City spoilers: Hope Is A Powerful Drug

Holby City Series 21 episode 42 ‘Hope Is A Powerful Drug’

Frankie returns to Holby and is keen to take Isla back. A worried Essie doesn’t believe Frankie is truly ready to be a mother; how does Essie convince Frankie Isla is better with her before it’s too late?

Serena returns to AAU and clashes with top neurosurgeon Max McGerry who has a radical idea to treat Ric’s tumour. Ric is forced to think about his options and makes his decision.

Jac returns from holiday and asserts her authority over an overworked and stressed out Kian.


Nic Jackman As Cameron Dunn
Amy Lennox As Chloe Godard
Ramin Karimloo As Kian Madani
Alex Walkinshaw As Adrian “Fletch” Fletcher
Belinda Owusu As Nicky Mckendrick
Hugh Quarshie As Ric Griffin
Marcus Griffiths As Xavier “Zav” Duval
Jaye Jacobs As Donna Jackson
Catherine Russell As Serena Campbell
Bob Barrett As Sacha Levy
Kaye Wragg As Essie Di Lucca
Rosie Marcel As Jac Naylor
Jo Martin As Max Mcgerry
Dawn Steele As Ange Godard
Joel Robinson As Callum Loveitt
Camilla Watson As Casey Fresle
Sophie Harkness As Frankie Rendell


Simon Norman – Writer
Amy Rodriguez – Producer
Griff Rowland – Director

This episode airs 15th October 2019 on BBC One at 8pm


  1. Fantastic programme! As a nurse years ago, I love it! Great acting and so convincing! All deserve an award. I will hire Jac any day to look after me!


  2. Well thanks for that we didnt know Rik had a Tumor last night he had just collapsed but now you have told us!!! Why do you do that to us viewers it’s so wrong grrrr


    1. This was due to come out before the episode aired so I haven’t shared nothing that wouldn’t have been written about


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